nemiralisib   Click here for help

GtoPdb Ligand ID: 9425

Synonyms: compound 2 [PMID: 26301626] | GSK-2269557 | GSK2269557
PDB Ligand Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: Nemiralisib (GSK2269557) is a PI3K inhibitor with selectivity for PI3Kδ over the other related isoforms [1]. The compound is active via inhalation and is being evaluated for its potential in respiratory inflammation. May be administered or used experimentally as the hydrochloride salt (PubChem CID 49784084). In the original study by Down et al. (2015) compound 3 (GSK2292767) was developed as a follow-up compound with reduced hERG activity and minimised systemic exposure [1].
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 5
Topological polar surface area 76.98
Molecular weight 440.23
XLogP 4.31
No. Lipinski's rules broken 0
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Canonical SMILES CC(N1CCN(CC1)Cc1cnc(o1)c1cc(cc2c1cn[nH]2)c1cccc2c1cc[nH]2)C
Isomeric SMILES CC(N1CCN(CC1)Cc1cnc(o1)c1cc(cc2c1cn[nH]2)c1cccc2c1cc[nH]2)C
InChI InChI=1S/C26H28N6O/c1-17(2)32-10-8-31(9-11-32)16-19-14-28-26(33-19)22-12-18(13-25-23(22)15-29-30-25)20-4-3-5-24-21(20)6-7-27-24/h3-7,12-15,17,27H,8-11,16H2,1-2H3,(H,29,30)
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
10314 nemiralisib
Synonyms Click here for help
compound 2 [PMID: 26301626] | GSK-2269557 | GSK2269557
Database Links Click here for help
BindingDB Ligand 50004529
CAS Registry No. 1254036-71-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL2216859
GtoPdb PubChem SID 328083525
PubChem CID 49784002
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UniChem Compound Search for chemical match using the InChIKey MCIDWGZGWVSZMK-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey MCIDWGZGWVSZMK-UHFFFAOYSA-N