Synonyms: (R)-lisophylline | CT-1501R
Compound class:
Synthetic organic
Comment: Lisophylline is an active metabolite of pentoxifylline. The compound has novel anti-inflammatory properties, likely through inhibition of IL-12 signalling and STAT-4 activation [2]. It is reported to prevent type 1 diabetes in preclinical models [3] and improve the function and viability of isolated or transplanted pancreatic islets [1]. Evidence suggests that combined treatment with lisofylline (for its anti-inflammatory action) and exendin-4 (to enhance beta-cell proliferation) can reverse autoimmune diabetes in the non-obese diabetic (NOD) mouse model [4].
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Classification ![]() |
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Compound class | Synthetic organic |
Prodrug | pentoxifylline |
IUPAC Name ![]() |
1-[(5R)-5-hydroxyhexyl]-3,7-dimethylpurine-2,6-dione |
International Nonproprietary Names ![]() |
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INN number | INN |
7322 | lisofylline |
Synonyms ![]() |
(R)-lisophylline | CT-1501R |
Database Links ![]() |
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CAS Registry No. | 100324-81-0 |
ChEMBL Ligand | CHEMBL1411 |
GtoPdb PubChem SID | 315661300 |
PubChem CID | 501254 |
Search Google for chemical match using the InChIKey | NSMXQKNUPPXBRG-SECBINFHSA-N |
Search Google for chemicals with the same backbone | NSMXQKNUPPXBRG |
Search PubMed clinical trials | lisofylline |
Search PubMed titles | lisofylline |
Search PubMed titles/abstracts | lisofylline |
UniChem Compound Search for chemical match using the InChIKey | NSMXQKNUPPXBRG-SECBINFHSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NSMXQKNUPPXBRG-SECBINFHSA-N |
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(R)-Lisofylline (links to external site)
Cat. No. HY-109854A |