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clazakizumab   Click here for help

GtoPdb Ligand ID: 9195

Synonyms: ALD-518 | ALD518 | BMS-945429
Immunopharmacology Ligand
Compound class: Antibody
Comment: Clazakizumab is an investigational, aglycosylated, humanized (from a rabbit parental antibody) monoclonal antibody targeting interleukin-6, with anti-inflammatory potential [2].
Peptide sequence and structural information for this antibody are available from its IMGT/mAb-db record. BLAST peptide sequence analysis reveals identical matches with peptides claimed in patent US8062864 [3]. Results presented in the patent show that the preferred antibodies block interaction of IL-6 with the IL-6 receptor, but no precise binding affinity data is provided.
Immunopharmacology Disease
Disease X-Refs Comment References
Rheumatoid arthritis Disease Ontology: DOID:7148
OMIM: 180300
 No progress beyond Phase 2 trial.
Psoriatic arthritis Disease Ontology: DOID:9008
 No progress beyond Phase 2 trial.