ARN726 is from a series of β-lactam derivatives that are potent, selective, and systemically active inhibitors of intracellular N
-Acylethanolamine acid amidase (NAAA) by covalently binding the enzyme's catalytic cysteine. It exhibits anti-inflammatory effects in both mouse models and human macrophages [2
]. In the corresponding patent [1
] the structure seems to be example 5. There is a patchy SAR table for 106 structures on page 104 of the WO2014144836 PDF. The R isomer of this structure PubChem CID 86282216
is reported to be less active.