flortaucipir (18F)   Click here for help

GtoPdb Ligand ID: 9100

Synonyms: 18F-AV-1451 | [F-18]T807 | flortaucipir F-18 | LY-3191748 | Tauvid®
 Ligand is labelled  Ligand is radioactive
Compound class: Synthetic organic
Comment: Flortaucipir (18F) is an investigational PET imaging agent (diagnostic radiopharmaceutical) designed to visualise tau protein (MAPT; P10636) in Alzheimer's disease brains. Compare with the approved agent, florbetapir, used to visualise β-amyloid.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 1
Topological polar surface area 41.57
Molecular weight 263.09
XLogP 3.22
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Fc1ccc(cn1)c1ccc2c(c1)[nH]c1c2cncc1
Isomeric SMILES [18F]c1ccc(cn1)c1ccc2c(c1)[nH]c1c2cncc1
InChI InChI=1S/C16H10FN3/c17-16-4-2-11(8-19-16)10-1-3-12-13-9-18-6-5-14(13)20-15(12)7-10/h1-9,20H/i17-1
InChI Key GETAAWDSFUCLBS-SJPDSGJFSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
7-(6-fluoranylpyridin-3-yl)-5H-pyrido[4,3-b]indole
International Nonproprietary Names Click here for help
INN number INN
10203 flortaucipir (18F)
Synonyms Click here for help
18F-AV-1451 | [F-18]T807 | flortaucipir F-18 | LY-3191748 | Tauvid®
Database Links Click here for help
CAS Registry No. 1522051-90-6 (source: WHO INHN record)
ChEMBL Ligand CHEMBL3545253
DrugCentral Ligand 5396
GtoPdb PubChem SID 315661185
PubChem CID 70957463
Search Google for chemical match using the InChIKey GETAAWDSFUCLBS-SJPDSGJFSA-N
Search Google for chemicals with the same backbone GETAAWDSFUCLBS
Search PubMed clinical trials flortaucipir
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Search PubMed titles/abstracts flortaucipir
UniChem Compound Search for chemical match using the InChIKey GETAAWDSFUCLBS-SJPDSGJFSA-N
UniChem Connectivity Search for chemical match using the InChIKey GETAAWDSFUCLBS-SJPDSGJFSA-N