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domagrozumab   Click here for help

GtoPdb Ligand ID: 9096

Synonyms: clone OGD1.0.0 [2] | PF-06252616 | PF06252616
Compound class: Antibody
Comment: Domagrozumab is a humanized monoclonal antibody targeting myostatin (MSTN), being investigated for potential therapeutic action in muscle wasting diseases.
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB record. Protein BLAST analysis reveals 100% matches with sequences claimed in patent US8992913 [2].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
myostatin Primary target of this compound Hs Antibody Binding 11.6 pKd - 2
⤷ pKd 11.6 (Kd 2.59x10-12 M) [2]