Compound class:
Synthetic organic
Comment: Compound 30 acts as a negative allosteric modulator of GLUT1-mediated glucose import in to tumour cells (LNCaP cells) and this effects apoptotic cell death [1].
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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References |
1. Wang D, Chu PC, Yang CN, Yan R, Chuang YC, Kulp SK, Chen CS. (2012)
Development of a novel class of glucose transporter inhibitors. J Med Chem, 55 (8): 3827-36. [PMID:22468970] |