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landogrozumab   Click here for help

GtoPdb Ligand ID: 8730

Synonyms: LY-2495655 | LY2495655
Compound class: Antibody
Comment: Landogrozumab is an investigational anti-myostatin, humanized, monoclonal antibody.
Peptide sequences and structural information for this antibody are available from its IMGT/mAb-DB record.
A BLAST protein search using the light and heavy chain variable regions of landogrozumab, identifies 100% matches with sequences patented in US7632499 B2 [2], and point towards clone 3-74/C1E4, as a preferred embodiment, taken forward for further anaylsis.
Bioactivity Comments
Affinity data in the table below is that provided in [2], for clone 3-74/C1E4.
Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
myostatin {Sp: Human} Peptide Primary target of this compound Hs Antibody Binding 11.9 pKd - 2
⤷ pKd 11.9 (Kd 1.39x10-12 M) [2]
Description: Measured using the Sapidyne KINEXA assay.