nesvacumab

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nesvacumab

GtoPdb Ligand ID: 8457

Synonyms: REGN-910 | REGN910 | SAR307746

Compound class: Antibody

Comment: Nesvacumab is a fully human monoclonal antibody that targets angiopoietin-2 (ANGPT2, aka ANG2), being investigated as an antiangiogenic anti-tumour agent.
Peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Summary
Biological activity
Clinical data
References

References
1. Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD et al.. (2013) Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition. Cancer Res, 73 (1): 108-18. [PMID:23149917]
2. Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE. (2013) Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy. Cancer Res, 73 (6): 1649-57. [PMID:23467610]

References

1. Daly C, Eichten A, Castanaro C, Pasnikowski E, Adler A, Lalani AS, Papadopoulos N, Kyle AH, Minchinton AI, Yancopoulos GD et al.. (2013)
Angiopoietin-2 functions as a Tie2 agonist in tumor models, where it limits the effects of VEGF inhibition.
Cancer Res, 73 (1): 108-18. [PMID:23149917]

2. Gerald D, Chintharlapalli S, Augustin HG, Benjamin LE. (2013)
Angiopoietin-2: an attractive target for improved antiangiogenic tumor therapy.
Cancer Res, 73 (6): 1649-57. [PMID:23467610]