filgotinib   Click here for help

GtoPdb Ligand ID: 7913

Synonyms: GLPG-0634 | GLPG0634 | Jyseleca®
Approved drug PDB Ligand Immunopharmacology Ligand
filgotinib is an approved drug (EMA (2020))
Compound class: Synthetic organic
Comment: Filgotinib is a selective and orally acive JAK1 inhibitor [3]. It is being developed in a collaboration between Gilead Sciences and Galapagos for the treatment of inflammatory indications including psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis and rheumatoid arthritis. It is proposed as a once daily drug, that is predicted to cause fewer toxicity issues and adverse effects than existing JAK1 inhibitors.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 7
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 105.05
Molecular weight 425.15
XLogP 1.99
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES O=C(C1CC1)Nc1nc2n(n1)c(ccc2)c1ccc(cc1)CN1CCS(=O)(=O)CC1
Isomeric SMILES O=C(C1CC1)Nc1nc2n(n1)c(ccc2)c1ccc(cc1)CN1CCS(=O)(=O)CC1
InChI InChI=1S/C21H23N5O3S/c27-20(17-8-9-17)23-21-22-19-3-1-2-18(26(19)24-21)16-6-4-15(5-7-16)14-25-10-12-30(28,29)13-11-25/h1-7,17H,8-14H2,(H,23,24,27)
InChI Key RIJLVEAXPNLDTC-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA (2020))
IUPAC Name Click here for help
N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide
International Nonproprietary Names Click here for help
INN number INN
9720 filgotinib
Synonyms Click here for help
GLPG-0634 | GLPG0634 | Jyseleca®
Database Links Click here for help
CAS Registry No. 1206161-97-8
ChEMBL Ligand CHEMBL3301607
GtoPdb PubChem SID 249565596
PubChem CID 49831257
RCSB PDB Ligand 2HB
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SynPHARM 80797 (in complex with Janus kinase 2)
85292 (in complex with Janus kinase 2)
Wikipedia Filgotinib