lofepramine   Click here for help

GtoPdb Ligand ID: 7551

Synonyms: Gamanil ® | Lomont ® | WHR-2908A
Approved drug
lofepramine is an approved drug
Compound class: Synthetic organic
Comment: Marketed formulations may contain lofepramine hydrochloride (PubChem CID 33611).
Click here for help
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: lofepramine

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 3
Hydrogen bond donors 0
Rotatable bonds 7
Topological polar surface area 23.55
Molecular weight 418.18
XLogP 6.01
No. Lipinski's rules broken 1
Click here for help
Canonical SMILES CN(CC(=O)c1ccc(cc1)Cl)CCCN1c2ccccc2CCc2c1cccc2
Isomeric SMILES CN(CC(=O)c1ccc(cc1)Cl)CCCN1c2ccccc2CCc2c1cccc2
InChI InChI=1S/C26H27ClN2O/c1-28(19-26(30)22-13-15-23(27)16-14-22)17-6-18-29-24-9-4-2-7-20(24)11-12-21-8-3-5-10-25(21)29/h2-5,7-10,13-16H,6,11-12,17-19H2,1H3
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes
Withdrawn drug? Yes
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
2909 lofepramine
Synonyms Click here for help
Gamanil ® | Lomont ® | WHR-2908A
Database Links Click here for help
CAS Registry No. 23047-25-8
ChEMBL Ligand CHEMBL87708
DrugCentral Ligand 1592
GtoPdb PubChem SID 223365887
PubChem CID 3947
Search Google for chemical match using the InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N
Search Google for chemicals with the same backbone SAPNXPWPAUFAJU
Search PubMed clinical trials lofepramine
Search PubMed titles lofepramine
Search PubMed titles/abstracts lofepramine
UniChem Compound Search for chemical match using the InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey SAPNXPWPAUFAJU-UHFFFAOYSA-N
Wikipedia Lofepramine

Product suppliers

View disclaimer

Lofepramine (links to external site)
Cat. No. 2545