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ixekizumab   Click here for help

GtoPdb Ligand ID: 7541

Synonyms: LY-2439821 | LY2439821 | Taltz®
Approved drug Immunopharmacology Ligand
ixekizumab is an approved drug (FDA & EMA (2016))
Compound class: Antibody
Comment: Ixekizumab binds to IL-17A and blocks its action.
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record. A protein BLAST search using the variable region of the heavy chain of ixekizumab identifies this as sequence 118 from patent US7838638 [1]. In this patent binding affinity data for human IL-17 is provided for several antibody clones, but it does not specify which was chosen as ixekizumab, although mAbs 126, 121 and 104 did undergo additional experimental investigations.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-17A Primary target of this compound Hs Antibody Binding >11.7 pKd - 1
⤷ pKd >11.7 (Kd <2x10-12 M) [1]
Description: Binding affinity of mAbs 104, 121 and 126 from patent US7838638