fluvoxamine   Click here for help

GtoPdb Ligand ID: 7189

Synonyms: Luvox® | U-23000
Approved drug PDB Ligand Immunopharmacology Ligand
fluvoxamine is an approved drug (FDA (1994))
Compound class: Synthetic organic
Comment: Fluvoxamine is an antidepressant belonging to the selective serotonin reuptake inhibitor (SSRI) drug group.
Marketed formulations may contain fluvoxamine maleate (PubChem CID 9560989).

SARS-CoV-2 and COVID-19: Evidence that is emerging from randomised, placebo-controlled clinical trials [6] suggests that fluvoxamine may offer potential as a therapuetic for non-hospitalised COVID-19 patients. Multiple fluvoxamine mechanisms of action may be at play [10], and much remains to clarified about the patients who would benefit most, efficacy in infections with different SARS-CoV-2 variants, and whether fluvoxamine's effect occurs in addition to the benefit demonstrated by other therapies.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 56.84
Molecular weight 318.16
XLogP 3.24
No. Lipinski's rules broken 0
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Canonical SMILES NCCO/N=C(/c1ccc(cc1)C(F)(F)F)\CCCCOC
Isomeric SMILES NCCO/N=C(/c1ccc(cc1)C(F)(F)F)\CCCCOC
InChI InChI=1S/C15H21F3N2O2/c1-21-10-3-2-4-14(20-22-11-9-19)12-5-7-13(8-6-12)15(16,17)18/h5-8H,2-4,9-11,19H2,1H3/b20-14+
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1994))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
3879 fluvoxamine
Synonyms Click here for help
Luvox® | U-23000
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9679783
Reactome Reaction Reactome logo R-HSA-9679780
Other databases
CAS Registry No. 54739-18-3
DrugBank Ligand DB00176
DrugCentral Ligand 1230
GtoPdb PubChem SID 178103764
PubChem CID 5324346
Search Google for chemical match using the InChIKey CJOFXWAVKWHTFT-XSFVSMFZSA-N
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UniChem Compound Search for chemical match using the InChIKey CJOFXWAVKWHTFT-XSFVSMFZSA-N
UniChem Connectivity Search for chemical match using the InChIKey CJOFXWAVKWHTFT-XSFVSMFZSA-N
Wikipedia Fluvoxamine