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chloroprocaine   Click here for help

GtoPdb Ligand ID: 7145

Synonyms: chloroprocaine hydrochloride | Nesacaine®
Approved drug
chloroprocaine is an approved drug (FDA (1955))
Compound class: Synthetic organic
Comment: Chloroprocaine is a short-acting ester anaesthetic. It has a significantly shorter duration of action than lidocaine and is significantly less toxic.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Click here for structure editor
Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 55.56
Molecular weight 270.11
XLogP 2.46
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CCN(CCOC(=O)c1ccc(cc1Cl)N)CC
Isomeric SMILES CCN(CCOC(=O)c1ccc(cc1Cl)N)CC
InChI InChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
InChI Key VDANGULDQQJODZ-UHFFFAOYSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes. US FDA (1955)
IUPAC Name Click here for help
2-(diethylamino)ethyl 4-amino-2-chlorobenzoate
International Nonproprietary Names Click here for help
INN number INN
487 chloroprocaine
Synonyms Click here for help
chloroprocaine hydrochloride | Nesacaine®
Database Links Click here for help
CAS Registry No. 133-16-4
ChEMBL Ligand CHEMBL1179047
DrugBank Ligand DB01161
DrugCentral Ligand 605
GtoPdb PubChem SID 178103720
PubChem CID 8612
Search Google for chemical match using the InChIKey VDANGULDQQJODZ-UHFFFAOYSA-N
Search Google for chemicals with the same backbone VDANGULDQQJODZ
Search PubMed clinical trials chloroprocaine
Search PubMed titles chloroprocaine
Search PubMed titles/abstracts chloroprocaine
UniChem Compound Search for chemical match using the InChIKey VDANGULDQQJODZ-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey VDANGULDQQJODZ-UHFFFAOYSA-N
Wikipedia Chloroprocaine