muromonab-CD3

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Synonyms: L04AA02 | OKT-3 | Orthoclone Okt3®

muromonab-CD3 is an approved drug (FDA (1992))

Compound class: Antibody

Comment: Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Immunopharmacology Comments
Muromonab-CD3 binds to CD3 on T cells and induces Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.

Immunopharmacology Comments

Muromonab-CD3 binds to CD3 on T cells and induces Fc mediated apoptosis, antibody mediated cytotoxicity and complement-dependent cytotoxicity.

Immunopharmacology Disease
Disease	X-Refs	Comment	References
Allograft rejection		Approved to prevent renal, cardiac and hepatic allograft rejection. Withdrawn from the US market.