cetuximab   Click here for help

GtoPdb Ligand ID: 6882

Synonyms: C225 | Erbitux® | IMC-225 | IMC-C225
Approved drug
cetuximab is an approved drug (Switzerland (2003), EMA & FDA (2004))
Compound class: Antibody
Comment: Cetuximab binds to and competitively inhibits the activity of the epidermal growth factor receptor (EGFR).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

Biosimilars:
As Bristol-Myers Squibb's original EU and US patents for cetuximab have expired, challengers of cetuximab's market position are developing biosimilar and/or biobetter cetuximab.
Celltrion's CT-P15 is a cetuximab biosimilar, intended for the treatment of colorectal cancer. MabTech-Sorrento's STI-001 is a proposed biobetter cetuximab (perhaps because synthesis in CHO cells creates a different glycosylation pattern to that of cetuximab which is made in mouse cells, and may be less likely to cause side-effects such as immunogenicity and hypersensitivity). STI-001 has completed Phase 3 clinical trial in China. Neither of these agents is associated with any clinical studies that are registered with ClinicalTrials.gov.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
Approved drug? Yes (Switzerland (2003), EMA & FDA (2004))
International Nonproprietary Names Click here for help
INN number INN
7906 cetuximab
Synonyms Click here for help
C225 | Erbitux® | IMC-225 | IMC-C225
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 151
Reactome Drug Reactome logo R-ALL-1248673
Reactome Reaction Reactome logo R-HSA-1248677
Other databases
GtoPdb PubChem SID 178103464
PubChem SID 178103464
Search PubMed clinical trials cetuximab
Search PubMed titles cetuximab
Search PubMed titles/abstracts cetuximab
Wikipedia Cetuximab