cetuximab   Click here for help

GtoPdb Ligand ID: 6882

Synonyms: C225 | Erbitux® | IMC-225 | IMC-C225
Approved drug
cetuximab is an approved drug (Switzerland (2003), EMA & FDA (2004))
Compound class: Antibody
Comment: Cetuximab binds to and competitively inhibits the activity of the epidermal growth factor receptor (EGFR).
Annotated peptide sequences for this antibody are available from its IMGT/mAb-DB record.

As Bristol-Myers Squibb's original EU and US patents for cetuximab have expired, challengers of cetuximab's market position are developing biosimilar and/or biobetter cetuximab.
Celltrion's CT-P15 is a cetuximab biosimilar, intended for the treatment of colorectal cancer. MabTech-Sorrento's STI-001 is a proposed biobetter cetuximab (perhaps because synthesis in CHO cells creates a different glycosylation pattern to that of cetuximab which is made in mouse cells, and may be less likely to cause side-effects such as immunogenicity and hypersensitivity). STI-001 has completed Phase 3 clinical trial in China. Neither of these agents is associated with any clinical studies that are registered with ClinicalTrials.gov.
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Classification Click here for help
Compound class Antibody
Approved drug? Yes (Switzerland (2003), EMA & FDA (2004))
International Nonproprietary Names Click here for help
INN number INN
7906 cetuximab
Synonyms Click here for help
C225 | Erbitux® | IMC-225 | IMC-C225
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 151
Reactome Drug Reactome logo R-ALL-1248673
Reactome Reaction Reactome logo R-HSA-1248677
Other databases
GtoPdb PubChem SID 178103464
PubChem SID 178103464
Search PubMed clinical trials cetuximab
Search PubMed titles cetuximab
Search PubMed titles/abstracts cetuximab
Wikipedia Cetuximab