fosinoprilat   Click here for help

GtoPdb Ligand ID: 6457

Synonyms: SQ-27519
Approved drug PDB Ligand
fosinoprilat is an approved drug (FDA (1991))
Compound class: Synthetic organic
Comment: Fosinoprilat is the active drug produced by metabolism of the prodrug fosinopril.
Click here for help

Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

✖

View interactive charts of activity data across species
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 6
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 104.72
Molecular weight 435.22
XLogP 4.25
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

✖
Canonical SMILES O=C(N1CC(CC1C(=O)O)C1CCCCC1)CP(=O)(CCCCc1ccccc1)O
Isomeric SMILES O=C(N1C[C@@H](C[C@H]1C(=O)O)C1CCCCC1)CP(=O)(CCCCc1ccccc1)O
InChI InChI=1S/C23H34NO5P/c25-22(17-30(28,29)14-8-7-11-18-9-3-1-4-10-18)24-16-20(15-21(24)23(26)27)19-12-5-2-6-13-19/h1,3-4,9-10,19-21H,2,5-8,11-17H2,(H,26,27)(H,28,29)/t20-,21+/m1/s1
InChI Key WOIWWYDXDVSWAZ-RTWAWAEBSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (1991))
Prodrug fosinopril
IUPAC Name Click here for help
(2S,4S)-4-cyclohexyl-1-[2-(hydroxy-(4-phenylbutyl)phosphoryl)acetyl]pyrrolidine-2-carboxylic acid
International Nonproprietary Names Click here for help
INN number INN
6555 fosinoprilat
Synonyms Click here for help
SQ-27519
Database Links Click here for help
Specialist databases
Reactome Drug Reactome logo R-ALL-9619011, R-ALL-9614921
Reactome Reaction Reactome logo R-HSA-9614933, R-HSA-9619034
Other databases
CAS Registry No. 95399-71-6 (source: PubChem)
ChEBI CHEBI:116962
ChEMBL Ligand CHEMBL581
GtoPdb PubChem SID 178103072
PubChem CID 62956
RCSB PDB Ligand KS8
Search Google for chemical match using the InChIKey WOIWWYDXDVSWAZ-RTWAWAEBSA-N
Search Google for chemicals with the same backbone WOIWWYDXDVSWAZ
Search PubMed clinical trials fosinoprilat
Search PubMed titles fosinoprilat
Search PubMed titles/abstracts fosinoprilat
UniChem Compound Search for chemical match using the InChIKey WOIWWYDXDVSWAZ-RTWAWAEBSA-N
UniChem Connectivity Search for chemical match using the InChIKey WOIWWYDXDVSWAZ-RTWAWAEBSA-N