Synonyms: Chir 258 | CHIR-258 | TKI 258 | TKI-258
Compound class:
Synthetic organic
Comment: Dovitinib is a multi-targeted receptor tyrosine kinase (RTK) inhibitor, with modest selectivity for Class III RTKs (IC50s 1-2nM), with IC50s for Class IV and V RTKs in the 8-13nM range. Please note that ChEMBL represents this compound as a tautomer of our structure.
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-1,3-benzodiazol-2-ylidene]-2,3-dihydroquinolin-2-one |
International Nonproprietary Names | |
INN number | INN |
8847 | dovitinib |
Synonyms |
Chir 258 | CHIR-258 | TKI 258 | TKI-258 |
Database Links | |
Specialist databases | |
Reactome Drug | R-ALL-1839035 |
Reactome Reaction | R-HSA-2077420, R-HSA-9669893, R-HSA-9669898, R-HSA-1839039, R-HSA-2023462 |
Other databases | |
CAS Registry No. | 405169-16-6 |
ChEMBL Ligand | CHEMBL522892 |
GtoPdb PubChem SID | 178102585 |
PubChem CID | 135398510 |
Search Google for chemical match using the InChIKey | KCOYQXZDFIIGCY-ZZEZOPTASA-N |
Search Google for chemicals with the same backbone | KCOYQXZDFIIGCY |
Search PubMed clinical trials | dovitinib |
Search PubMed titles | dovitinib |
Search PubMed titles/abstracts | dovitinib |
UniChem Compound Search for chemical match using the InChIKey | KCOYQXZDFIIGCY-ZZEZOPTASA-N |
UniChem Connectivity Search for chemical match using the InChIKey | KCOYQXZDFIIGCY-ZZEZOPTASA-N |