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thymic stromal lymphopoietin   Click here for help

GtoPdb Ligand ID: 5083

Abbreviated name: TSLP
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: Thymic stromal lymphopoietin (TLSP), an IL-7 like cytokine, is the endogenous ligand for the TLSP receptor. TLSP/TLSPR signalling is pro-inflammatory.
Species: Human
Natural/Endogenous Targets
Target
Thymic stromal lymphopoietin receptor
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
Thymic stromal lymphopoietin receptor Ligand is endogenous in the given species Hs Agonist Agonist - - -
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Other ligands which bind to or alter the activity of this ligand
Key to terms and symbols Click column headers to sort
Ligand Sp. Type Action Value Parameter Concentration range (M) Reference
tezepelumab Peptide Approved drug Primary target of this compound Hs Antibody Binding 10.5 – 10.8 pKd - 2
⤷ pKd 10.5 – 10.8 (Kd 2.92x10-11 – 1.58x10-11 M) [2]