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TWEAK   Click here for help

GtoPdb Ligand ID: 5067

Synonyms: Apo-3 ligand (Apo3L) | CD255 | TNF-related weak inducer of apoptosis | Tumor necrosis factor ligand superfamily member 12, membrane form
Compound class: Endogenous peptide in human, mouse or rat
Comment: TWEAK protein (TNFSF12) is a tumor necrosis factor (TNF) family cytokine that exists in both membrane-bound and secreted forms. It acts via interaction with the TWEAK receptor (encoded by the TNFRSF12A gene), and is a modulator of endothelial cell proliferation and migration, and is therefore an angiogenesis regulator.
Species: Human
Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Tumor necrosis factor superfamily ligands
Synonyms Click here for help
Apo-3 ligand (Apo3L) | CD255 | TNF-related weak inducer of apoptosis | Tumor necrosis factor ligand superfamily member 12, membrane form
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
TNFSF12 TNF superfamily member 12 Human prepro-tumor necrosis factor ligand superfamily member 12 APO3L, DR3LG, tumor necrosis factor (ligand) superfamily, member 12, tumor necrosis factor superfamily member 12, TWEAK
Database Links Click here for help
CATH/Gene3D 2.60.120.40
Ensembl Gene ENSG00000239697 (Hs)
GtoPdb PubChem SID 178101760
Human Protein Atlas ENSG00000239697 (Hs)
UniProtKB O43508 (Hs)
Wikipedia TNFSF12