IL-5

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Ligands
IL-5 (Human)

GtoPdb Ligand ID: 4997

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-5 is one of the hematopoietic family cytokines. Unlike other family members IL-3 and GM-CSF, IL-5 is a homodimer, consisting of two identical amino acid chains linked by two disulphide bonds

Species: Human

References
1. Bodmer MW, Athwal DS, Emtage JS. (1999) Interleukin-5 specific recombinant antibodies. Patent number: US5998586. Assignee: Celltech Therapeutics, Limited. Priority date: 17/06/1994. Publication date: 07/12/1999.
2. Hart TK, Cook RM, Zia-Amirhosseini P, Minthorn E, Sellers TS, Maleeff BE, Eustis S, Schwartz LW, Tsui P, Appelbaum ER et al.. (2001) Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys. J Allergy Clin Immunol, 108 (2): 250-7. [PMID:11496242]
3. Liddament MT, Doyle A, Clarke A, Laine DJS, Cooksey BA. (2018) Anti-il-5 antibodies. Patent number: WO2018119016A1. Assignee: Cephalon, Inc.. Priority date: 23/12/2016. Publication date: 28/06/2018.
4. Takatsu K. (2011) Interleukin-5 and IL-5 receptor in health and diseases. Proc Jpn Acad, Ser B, Phys Biol Sci, 87 (8): 463-85. [PMID:21986312]

References

1. Bodmer MW, Athwal DS, Emtage JS. (1999)
Interleukin-5 specific recombinant antibodies.
Patent number: US5998586. Assignee: Celltech Therapeutics, Limited. Priority date: 17/06/1994. Publication date: 07/12/1999.

2. Hart TK, Cook RM, Zia-Amirhosseini P, Minthorn E, Sellers TS, Maleeff BE, Eustis S, Schwartz LW, Tsui P, Appelbaum ER et al.. (2001)
Preclinical efficacy and safety of mepolizumab (SB-240563), a humanized monoclonal antibody to IL-5, in cynomolgus monkeys.
J Allergy Clin Immunol, 108 (2): 250-7. [PMID:11496242]

3. Liddament MT, Doyle A, Clarke A, Laine DJS, Cooksey BA. (2018)
Anti-il-5 antibodies.
Patent number: WO2018119016A1. Assignee: Cephalon, Inc.. Priority date: 23/12/2016. Publication date: 28/06/2018.

4. Takatsu K. (2011)
Interleukin-5 and IL-5 receptor in health and diseases.
Proc Jpn Acad, Ser B, Phys Biol Sci, 87 (8): 463-85. [PMID:21986312]