IL-31

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Ligands
IL-31 (Human)

GtoPdb Ligand ID: 4995

Synonyms: interleukin-31

Compound class: Endogenous peptide in human, mouse or rat

Comment: IL-31 is an IL-6 family cytokine.

Species: Human

References
1. Baron JM, Lüscher B. (2012) IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis. Acta Derm Venereol, 92 (1): 5-6. [PMID:22215012]
2. Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B. (2012) Signaling by IL-31 and functional consequences. Eur J Cell Biol, 91 (6-7): 552-66. [PMID:21982586]
3. Kim S, Kim HJ, Yang HS, Kim E, Huh IS, Yang JM. (2011) IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis. Ann Dermatol, 23 (4): 468-73. [PMID:22148014]
4. Lee CH, Yu HS. (2011) Biomarkers for itch and disease severity in atopic dermatitis. Curr Probl Dermatol, 41: 136-48. [PMID:21576954]
5. Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC et al.. (2017) Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody. J Eur Acad Dermatol Venereol, 31 (1): 142-150. [PMID:27501029]
6. Nemoto O, Furue M, Nakagawa H, Shiramoto M, Hanada R, Matsuki S, Imayama S, Kato M, Hasebe I, Taira K et al.. (2016) The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study. Br J Dermatol, 174 (2): 296-304. [PMID:26409172]
7. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J et al.. (2006) IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol, 117 (2): 411-7. [PMID:16461142]
8. Sprecher CA, Kuijper JK, Dasovich MM, Grant FJ, Hammond AK, Novak JE, Gross JA, Dillon SR. (2004) Novel cytokine zcytor17 ligand. Patent number: WO03060090 (A2). Assignee: Zymogenetics Inc.. Priority date: 18/01/2002. Publication date: 10/04/2004.
9. Storan ER, O'Gorman SM, McDonald ID, Steinhoff M. (2015) Role of cytokines and chemokines in itch. Handb Exp Pharmacol, 226: 163-76. [PMID:25861779]

References

1. Baron JM, Lüscher B. (2012)
IL-31 expression by inflammatory cells is preferentially elevated in atopic dermatitis.
Acta Derm Venereol, 92 (1): 5-6. [PMID:22215012]

2. Cornelissen C, Lüscher-Firzlaff J, Baron JM, Lüscher B. (2012)
Signaling by IL-31 and functional consequences.
Eur J Cell Biol, 91 (6-7): 552-66. [PMID:21982586]

3. Kim S, Kim HJ, Yang HS, Kim E, Huh IS, Yang JM. (2011)
IL-31 Serum Protein and Tissue mRNA Levels in Patients with Atopic Dermatitis.
Ann Dermatol, 23 (4): 468-73. [PMID:22148014]

4. Lee CH, Yu HS. (2011)
Biomarkers for itch and disease severity in atopic dermatitis.
Curr Probl Dermatol, 41: 136-48. [PMID:21576954]

5. Lewis KE, Holdren MS, Maurer MF, Underwood S, Meengs B, Julien SH, Byrnes-Blake KA, Freeman JA, Bukowski TR, Wolf AC et al.. (2017)
Interleukin (IL) 31 induces in cynomolgus monkeys a rapid and intense itch response that can be inhibited by an IL-31 neutralizing antibody.
J Eur Acad Dermatol Venereol, 31 (1): 142-150. [PMID:27501029]

6. Nemoto O, Furue M, Nakagawa H, Shiramoto M, Hanada R, Matsuki S, Imayama S, Kato M, Hasebe I, Taira K et al.. (2016)
The first trial of CIM331, a humanized antihuman interleukin-31 receptor A antibody, in healthy volunteers and patients with atopic dermatitis to evaluate safety, tolerability and pharmacokinetics of a single dose in a randomized, double-blind, placebo-controlled study.
Br J Dermatol, 174 (2): 296-304. [PMID:26409172]

7. Sonkoly E, Muller A, Lauerma AI, Pivarcsi A, Soto H, Kemeny L, Alenius H, Dieu-Nosjean MC, Meller S, Rieker J et al.. (2006)
IL-31: a new link between T cells and pruritus in atopic skin inflammation.
J Allergy Clin Immunol, 117 (2): 411-7. [PMID:16461142]

8. Sprecher CA, Kuijper JK, Dasovich MM, Grant FJ, Hammond AK, Novak JE, Gross JA, Dillon SR. (2004)
Novel cytokine zcytor17 ligand.
Patent number: WO03060090 (A2). Assignee: Zymogenetics Inc.. Priority date: 18/01/2002. Publication date: 10/04/2004.

9. Storan ER, O'Gorman SM, McDonald ID, Steinhoff M. (2015)
Role of cytokines and chemokines in itch.
Handb Exp Pharmacol, 226: 163-76. [PMID:25861779]