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IL-12   Click here for help

GtoPdb Ligand ID: 4977

Synonyms: IL-12 p70
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: This is the signature member of the IL-12 family of cytokines. Structurally it is a heterodimer consisting of IL-12A (p35) and IL-12B (p40) subunits. An interchain disulphide bond between cysteine residue 74 in the IL-12A chain and 177 in the IL-12B chain link the heterodimer. IL-27 and IL-23 share homology with IL-12 at the subunit, receptor, and signalling levels, but each performs specific roles in the regulation of immune responses to infection, inflammation and also in the pathophysiology of autoimmune disorders [1].
Species: Human
Immunopharmacology Comments
IL-12 family cytokines are key players in the regulation of T cell responses, produced by monocytes, macrophages, and dendritic cells in response to infection.