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IFN-β   Click here for help

GtoPdb Ligand ID: 4967

Synonyms: Avonex® (recombinant IFN-beta-1a) | fibroblast interferon | interferon beta
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: IFN-β is a type I IFN. The peptide sequence of the clinically used recombinant protein IFN-beta-1a is identical to that of the endogenous peptide.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Gulla Sv, Huard C, Buhlmann JE, Almagro JC, Kodangattil SR, Greenberg SA, LaVallie ER, Bennett EM, Hall JP et al.. (2020)
Interferon beta antibodies and uses thereof.
Patent number: US10829553B2. Assignee: Pfizer Corp SRL, Brigham and Womens Hospital Inc. Priority date: 28/04/2017. Publication date: 10/11/2020.
2. Zhang G, deWeerd NA, Stifter SA, Liu L, Zhou B, Wang W, Zhou Y, Ying B, Hu X, Matthews AY et al.. (2018)
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans.
Nat Commun, 9 (1): 85. [PMID:29311663]