B and T lymphocyte attenuator

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Ligands
B and T lymphocyte attenuator (Human)

GtoPdb Ligand ID: 4891

Abbreviated name: BTLA

Synonyms: B- and T-lymphocyte attenuator | B- and T-lymphocyte-associated protein | CD272

Compound class: Endogenous peptide in human, mouse or rat

Comment: BTLA is a negative immunomodulator. Interaction of BTLA with TNFRSF14 (HVEM) constitutes an immune checkpoint which inhibits T cell-mediated immune responses. Dysregulated BTLA expression contributes to immunosuppression and progression of some cancers [3-6] by enabling tumour immune evasion. Immunotherapeutics that block the BTLA-HVEM checkpoint offer potential as anti-tumour agents [8-9]. In the setting of inflammatory diseases anti-BTLA antibodies can induce inhibitory signalling and block T cell activation, thus reducing pro-inflammatory cytokine secretion [1].

Several anti-BTLA monoclonals have been progressed to clinical trials. Examples include:
Radanstobart (HFB200603, HiFiBiO; Phase 1 NCT05789069, solid tumours) [2]
Zadoprubart (ANB032, AnaptysBio; Phase 2 NCT05935085, atopic dermatitis; terminated due to insufficient efficacy) [1]
Venanprubart (LY3361237; development for autoimmune conditions terminated at Phase 2)
Tifcemalimab (JS004, icatolimab; Junshi Biosciences for advanced/metaststic solid tumours) [7]
GS-0272 (formerly MB272; Phase 1 NCT06031415 for rheumatoid arthritis was terminated).

Species: Human

Immunopharmacology Comments
BTLA is principally expressed on T and B lymphocytes, dendritic cells and macrophages. Interaction with its binding partner HVEM constitutes a co-inhibitory (immunosuppressive) checkpoint that controls the activation of BTLA-expressing immune cells.

Immunopharmacology Comments

BTLA is principally expressed on T and B lymphocytes, dendritic cells and macrophages. Interaction with its binding partner HVEM constitutes a co-inhibitory (immunosuppressive) checkpoint that controls the activation of BTLA-expressing immune cells.