Synonyms: Amitiza® | SPI-0211
lubiprostone is an approved drug (FDA (2006))
Compound class:
Synthetic organic
Comment: Chemically lubiprostone is a bicyclic fatty acid derived from prostaglandin E1 (PGE1). It acts as selective activator of ClC-2 chloride channels located at the apical aspect of gastrointestinal epithelial cells.
![]() View more information in the IUPHAR Pharmacology Education Project: lubiprostone |
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Classification ![]() |
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Compound class | Synthetic organic |
Approved drug? | Yes (FDA (2006)) |
Approved drug? | Yes. FDA (2006) |
IUPAC Name ![]() |
7-[(2R,4aR,5R,7aR)-2-(1,1-difluoropentyl)-2-hydroxy-6-oxo-3,4,4a,5,7,7a-hexahydrocyclopenta[e]pyran-5-yl]heptanoic acid |
International Nonproprietary Names ![]() |
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INN number | INN |
8254 | lubiprostone |
Synonyms ![]() |
Amitiza® | SPI-0211 |
Database Links ![]() |
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CAS Registry No. | 333963-40-9 (source: Scifinder) |
ChEMBL Ligand | CHEMBL1201134 |
DrugBank Ligand | DB01046 |
DrugCentral Ligand | 4123 |
GtoPdb PubChem SID | 178101059 |
PubChem CID | 157920 |
Search Google for chemical match using the InChIKey | WGFOBBZOWHGYQH-MXHNKVEKSA-N |
Search Google for chemicals with the same backbone | WGFOBBZOWHGYQH |
Search PubMed clinical trials | lubiprostone |
Search PubMed titles | lubiprostone |
Search PubMed titles/abstracts | lubiprostone |
UniChem Compound Search for chemical match using the InChIKey | WGFOBBZOWHGYQH-MXHNKVEKSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | WGFOBBZOWHGYQH-MXHNKVEKSA-N |
Wikipedia | Lubiprostone |