sovateltide   Click here for help

GtoPdb Ligand ID: 3886

Synonyms: IRL 1620 | IRL-1620 | IRL2620 | PMZ-1620 | SPI-1620 | Suc[Glu9,Ala11,15]ET-110-21 | Tycamzzi®
Approved drug
sovateltide is an approved drug (India CDSCO (2023))
Compound class: Peptide or derivative
Comment: Sovateltide (previously IRL-1620 and PMZ-1620) is a selective endothelin-B receptor (ETB) agonist. It is proposed as a mechanism to improve formation of new mature neurons and blood vessels in acute cerebral ischemia [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES CCC(C(C(=O)NC(C(=O)NC(C(=O)O)Cc1c[nH]c2c1cccc2)C(CC)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(C)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)CCC(=O)O)CC(=O)O)CCC(=O)O)CCC(=O)O)C)Cc1ccc(cc1)O)Cc1ccccc1)C)Cc1nc[nH]c1)CC(C)C)CC(=O)O)C
Isomeric SMILES CC[C@@H]([C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1c[nH]c2c1cccc2)[C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CCC(=O)O)CC(=O)O)CCC(=O)O)CCC(=O)O)C)Cc1ccc(cc1)O)Cc1ccccc1)C)Cc1nc[nH]c1)CC(C)C)CC(=O)O)C
InChI InChI=1S/C86H117N17O27/c1-11-44(7)71(84(127)100-63(86(129)130)35-50-39-88-54-21-17-16-20-53(50)54)103-85(128)72(45(8)12-2)102-82(125)62(38-69(114)115)98-78(121)57(32-42(3)4)96-80(123)60(36-51-40-87-41-89-51)95-73(116)46(9)91-77(120)58(33-48-18-14-13-15-19-48)97-79(122)59(34-49-22-24-52(104)25-23-49)99-83(126)70(43(5)6)101-74(117)47(10)90-75(118)55(26-29-65(106)107)93-76(119)56(27-30-66(108)109)94-81(124)61(37-68(112)113)92-64(105)28-31-67(110)111/h13-25,39-47,55-63,70-72,88,104H,11-12,26-38H2,1-10H3,(H,87,89)(H,90,118)(H,91,120)(H,92,105)(H,93,119)(H,94,124)(H,95,116)(H,96,123)(H,97,122)(H,98,121)(H,99,126)(H,100,127)(H,101,117)(H,102,125)(H,103,128)(H,106,107)(H,108,109)(H,110,111)(H,112,113)(H,114,115)(H,129,130)/t44-,45-,46-,47-,55-,56-,57-,58-,59-,60-,61-,62-,63-,70-,71-,72-/m0/s1
InChI Key DXPHNGAMYPPTBJ-TZMIJSMNSA-N
Classification Click here for help
Compound class Peptide or derivative
Approved drug? Yes (India CDSCO (2023))
International Nonproprietary Names Click here for help
INN number INN
11139 sovateltide
Synonyms Click here for help
IRL 1620 | IRL-1620 | IRL2620 | PMZ-1620 | SPI-1620 | Suc[Glu9,Ala11,15]ET-110-21 | Tycamzzi®
Database Links Click here for help
Specialist databases
GPCRdb Ligand sovateltide
Other databases
CAS Registry No. 142569-99-1 (source: Scifinder)
ChEMBL Ligand CHEMBL3188091
GtoPdb PubChem SID 178100722
PubChem CID 16133819
Search Google for chemical match using the InChIKey DXPHNGAMYPPTBJ-TZMIJSMNSA-N
Search Google for chemicals with the same backbone DXPHNGAMYPPTBJ
Search PubMed clinical trials sovateltide
Search PubMed titles sovateltide
Search PubMed titles/abstracts sovateltide
UniChem Compound Search for chemical match using the InChIKey DXPHNGAMYPPTBJ-TZMIJSMNSA-N
UniChem Connectivity Search for chemical match using the InChIKey DXPHNGAMYPPTBJ-TZMIJSMNSA-N

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Tocris
IRL-1620 (links to external site)
Cat. No. 1196