XCL1   Click here for help

GtoPdb Ligand ID: 3647

Synonyms: c motif cytokine 1 | cytokine SCM-1α | lymphotactin α
Immunopharmacology Ligand
Compound class: Endogenous peptide in human, mouse or rat
Comment: XCL1 is a C class chemokine also known as lymphotactin.
Species: Human
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Immunopharmacology Comments
XCL1 is produced by T, NK, and NK T cells during infectious and inflammatory responses [4]. Its receptor XCR1 is expressed by a subset of dendritic cells. Constitutive expression of XCL1 and XCR1 in the thymus regulates the thymic establishment of self-tolerance and the generation of regulatory T cells. XCL1 expression is increased in various autoimmune diseases in human and mouse [1-2,5].