zumilokibart

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Ligands
zumilokibart

GtoPdb Ligand ID: 14544

Synonyms: APG-777 | APG777

Compound class: Antibody

Comment: Zumilokibart (APG-777) is an interleukin 13 (IL-13) neutralising monoclonal antibody [1,3]. It is engineered to have an extended circulating half-life [2].

References
1. Rubio D, Zhu E, Thurston A, Funk KA, York KA, Dambkowski CL, Badger D. (2025) Preclinical Safety of APG777, A Novel Extended Half-Life Anti-Interleukin-13 Monoclonal Antibody, in Cynomolgus Monkeys. Int J Toxicol, 44 (6): 443-450. [PMID:40739793]
2. Yilmaz O, Torres T. (2024) Extended Half-life Antibodies: A Narrative Review of a New Approach in the Management of Atopic Dermatitis. Dermatol Ther (Heidelb), 14 (9): 2393-2406. [PMID:39147994]
3. Zhu E, Prentice H, Oh J, Shaheen H, Gandhi NA, Wickman G, Dabora R, Dambkowski CL, Dillinger L. (2025) In vitro potency and pharmacokinetics of APG777, a novel anti-IL-13 mAb. J Allergy Clin Immunol Glob, 4 (4): 100545. [PMID:40933957]

References

1. Rubio D, Zhu E, Thurston A, Funk KA, York KA, Dambkowski CL, Badger D. (2025)
Preclinical Safety of APG777, A Novel Extended Half-Life Anti-Interleukin-13 Monoclonal Antibody, in Cynomolgus Monkeys.
Int J Toxicol, 44 (6): 443-450. [PMID:40739793]

2. Yilmaz O, Torres T. (2024)
Extended Half-life Antibodies: A Narrative Review of a New Approach in the Management of Atopic Dermatitis.
Dermatol Ther (Heidelb), 14 (9): 2393-2406. [PMID:39147994]

3. Zhu E, Prentice H, Oh J, Shaheen H, Gandhi NA, Wickman G, Dabora R, Dambkowski CL, Dillinger L. (2025)
In vitro potency and pharmacokinetics of APG777, a novel anti-IL-13 mAb.
J Allergy Clin Immunol Glob, 4 (4): 100545. [PMID:40933957]