zumilokibart

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Ligands
zumilokibart

GtoPdb Ligand ID: 14544

Synonyms: APG-777 | APG777

Compound class: Antibody

Comment: Zumilokibart (APG-777) is an interleukin 13 (IL-13) neutralising monoclonal antibody [1,3]. It is engineered to have an extended circulating half-life [2].

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Binding to IL-13 prevents formation of the functionally active IL-13/IL‐13Rα1/IL‐4Rα complex, that would otherwise induce an inflammatory response via the JAK1/2-STAT6 pathway.

Immunopharmacology Comments

Binding to IL-13 prevents formation of the functionally active IL-13/IL‐13Rα1/IL‐4Rα complex, that would otherwise induce an inflammatory response via the JAK1/2-STAT6 pathway.