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zumilokibart   Click here for help

GtoPdb Ligand ID: 14544

Synonyms: APG-777 | APG777
Immunopharmacology Ligand
Compound class: Antibody
Comment: Zumilokibart (APG-777) is an interleukin 13 (IL-13) neutralising monoclonal antibody [1,3]. It is engineered to have an extended circulating half-life [2].
Bioactivity Comments
Cross-reacts with human and non-human primate IL-13, but not with mouse or rat IL-13 [3].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-13 Hs Antibody Binding 10.1 pKd - 3
⤷ pKd 10.1 (Kd 7.7x10-11 M) [3]
Description: Binding affinity determined by SPR