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pivekimab sunirine   Click here for help

GtoPdb Ligand ID: 14543

Synonyms: Decnupaz® | IMGN 632 | IMGN-632 | IMGN632 | pivekimab sunirine-pvzy | PVEK [2]
Approved drug
pivekimab sunirine is an approved drug
Compound class: Antibody
Comment: Pivekimab sunirine (IMGN632) is an interleukin 3 receptor subunit alpha (IL3RA) antibody-drug conjugate [2,4]. The payload is a DNA mono-alkylating compound (a monoamine indolinobenzodiazepine pseudodimer) [1]. The antibody is intended to deliver the toxic conjugate to neoplastic blood cells that overexpress IL3RA [5-6].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Classification Click here for help
Compound class Antibody
Approved drug? Yes. US FDA (2026)
International Nonproprietary Names Click here for help
INN number INN
11695 pivekimab sunirine
Synonyms Click here for help
Decnupaz® | IMGN 632 | IMGN-632 | IMGN632 | pivekimab sunirine-pvzy | PVEK [2]
Database Links Click here for help
Specialist databases
IMGT/mAb-DB 879
Other databases
Search PubMed clinical trials pivekimab sunirine
Search PubMed titles pivekimab sunirine
Search PubMed titles/abstracts pivekimab sunirine