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A515   Click here for help

GtoPdb Ligand ID: 14531

Synonyms: compound 15 [PMID: 38180485] | PD216595
Compound class: Synthetic organic
Comment: A515 is a VHL-binding [3] PROTAC degrader of SWI/SNF related BAF chromatin remodeling complex subunit ATPase 2 (SMARCA2; BRM) [2].
A515 has been conjugated to antibodies (creating degrader-antibody conjugates, or DACs) to demonstrate the potential of selective antibody-mediated delivery of the PROTAC to target tumour cells [1].
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 17
Hydrogen bond donors 4
Rotatable bonds 20
Topological polar surface area 243.64
Molecular weight 1041.27
XLogP 5.06
No. Lipinski's rules broken 4

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

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Canonical SMILES CC(C)[C@H](C1=CC(=NO1)OCCN2CCN(CCOC3=CC(=CC=N3)N4C5CCC4CN(C5)C6=CC(=NN=C6N)C7=C(C=CC=C7)O)[C@H](C)C2)C(=O)N8C[C@@H](C[C@H]8C(=O)N[C@@H](C)C9=CC=C(C=C9)C%10=C(C)N=CS%10)O
Isomeric SMILES S1C=NC(C)=C1C=2C=CC([C@H](C)NC([C@H]3N(C(=O)[C@H](C(C)C)C=4ON=C(OCCN5CCN(CCOC=6N=CC=C(N7C8CCC7CN(C9=C(N)N=NC(C=%10C(O)=CC=CC%10)=C9)C8)C6)[C@H](C)C5)C4)C[C@H](O)C3)=O)=CC2
InChI InChI=1S/C55H68N12O7S/c1-33(2)51(55(71)66-31-42(68)25-46(66)54(70)59-35(4)37-10-12-38(13-11-37)52-36(5)58-32-75-52)48-27-50(62-74-48)73-22-20-63-18-19-64(34(3)28-63)21-23-72-49-24-39(16-17-57-49)67-40-14-15-41(67)30-65(29-40)45-26-44(60-61-53(45)56)43-8-6-7-9-47(43)69/h6-13,16-17,24,26-27,32-35,40-42,46,51,68-69H,14-15,18-23,25,28-31H2,1-5H3,(H2,56,61)(H,59,70)/t34-,35+,40?,41?,42-,46+,51-/m1/s1
InChI Key RLQXXYROWQGBLA-UYJMYZDASA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Classification Click here for help
Compound class Synthetic organic
Ligand families/groups PROTACs, molecular glues and other degraders
IUPAC Name Click here for help
(2S,4R)-1-[(2R)-2-[3-[2-[(3R)-4-[2-[[4-[3-[3-amino-6-(2-hydroxyphenyl)pyridazin-4-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]-2-pyridinyl]oxy]ethyl]-3-methylpiperazin-1-yl]ethoxy]-1,2-oxazol-5-yl]-3-methylbutanoyl]-4-hydroxy-N-[(1S)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]ethyl]pyrrolidine-2-carboxamide
Synonyms Click here for help
compound 15 [PMID: 38180485] | PD216595
Database Links Click here for help
ChEMBL Ligand CHEMBL5572273
PubChem CID 139546285
Search Google for chemical match using the InChIKey RLQXXYROWQGBLA-UYJMYZDASA-N
Search Google for chemicals with the same backbone RLQXXYROWQGBLA
UniChem Compound Search for chemical match using the InChIKey RLQXXYROWQGBLA-UYJMYZDASA-N
UniChem Connectivity Search for chemical match using the InChIKey RLQXXYROWQGBLA-UYJMYZDASA-N