dazukibart

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Ligands
dazukibart

GtoPdb Ligand ID: 14524

Synonyms: PF-06823859 | PF06823859

Compound class: Antibody

Comment: Dazukibart (PF-06823859) is a humanized monoclonal antibody that selectively neutralises interferon-beta (IFN-β) and blocks signalling via interferon receptors (IFNAR) [1]. Peptide sequences for the heavy and light chains of dazukibart are claimed as components of antibody CTI-AF1 in Pfizer's patent US10829553 [2].

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Dazukibart is intended to treat chronic, multi-system inflammatory conditions that are driven by type I interferon (IFN) dysregulation. It is selective for IFN-β over IFN-α.

Immunopharmacology Comments

Dazukibart is intended to treat chronic, multi-system inflammatory conditions that are driven by type I interferon (IFN) dysregulation. It is selective for IFN-β over IFN-α.