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dazukibart   Click here for help

GtoPdb Ligand ID: 14524

Synonyms: PF-06823859 | PF06823859
Immunopharmacology Ligand
Compound class: Antibody
Comment: Dazukibart (PF-06823859) is a humanized monoclonal antibody that selectively neutralises interferon-beta (IFN-β) and blocks signalling via interferon receptors (IFNAR) [1]. Peptide sequences for the heavy and light chains of dazukibart are claimed as components of antibody CTI-AF1 in Pfizer's patent US10829553 [2].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IFN-β Hs Antibody Binding 10.4 pKd - 2
⤷ pKd 10.4 (Kd 3.6x10-11 M) [2]
Description: Binding affinity of antibody CTI-AF1 for hIFNβ determined by SPR