tegoprubart

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tegoprubart

GtoPdb Ligand ID: 14508

Synonyms: AT-1501 | AT1501

Compound class: Antibody

Comment: Tegoprubart (AT-1501) is a monoclonal antibody that targets human CD40 ligand (CD40LG; CD154). Signalling via the CD40-CD40L costimulatory pathway is a recognized mechanism that can drive transplant (graft) rejection and inhibition/blockade of this pathway is considered as a potential therapeutic approach to achieve transplant tolerance and graft survival [3-5]. Tegoprubart is modified to prevent FcγRII receptor-mediated platelet activation and reduce the risk of drug-induced thromboembolic events.

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Tegoprubart is proposed to act as an immunosuppressant, and was designed to prevent CD40L pathway-induced transplant rejection [1].

Immunopharmacology Comments

Tegoprubart is proposed to act as an immunosuppressant, and was designed to prevent CD40L pathway-induced transplant rejection [1].