tegoprubart

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tegoprubart

GtoPdb Ligand ID: 14508

Synonyms: AT-1501 | AT1501

Compound class: Antibody

Comment: Tegoprubart (AT-1501) is a monoclonal antibody that targets human CD40 ligand (CD40LG; CD154). Signalling via the CD40-CD40L costimulatory pathway is a recognized mechanism that can drive transplant (graft) rejection and inhibition/blockade of this pathway is considered as a potential therapeutic approach to achieve transplant tolerance and graft survival [3-5]. Tegoprubart is modified to prevent FcγRII receptor-mediated platelet activation and reduce the risk of drug-induced thromboembolic events.

No information available.

No information available.

Summary of Clinical Use
Tegoprubart (AT-1501) was progressed to clinical trials, as an immunosuppressant. The FDA granted orphan drug designation in March 2026, as a preventative agent to block liver transplant rejection [2].

Summary of Clinical Use

Tegoprubart (AT-1501) was progressed to clinical trials, as an immunosuppressant. The FDA granted orphan drug designation in March 2026, as a preventative agent to block liver transplant rejection [2].