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tegoprubart   Click here for help

GtoPdb Ligand ID: 14508

Synonyms: AT-1501 | AT1501
Immunopharmacology Ligand
Compound class: Antibody
Comment: Tegoprubart (AT-1501) is a monoclonal antibody that targets human CD40 ligand (CD40LG; CD154). Signalling via the CD40-CD40L costimulatory pathway is a recognized mechanism that can drive transplant (graft) rejection and inhibition/blockade of this pathway is considered as a potential therapeutic approach to achieve transplant tolerance and graft survival [3-5]. Tegoprubart is modified to prevent FcγRII receptor-mediated platelet activation and reduce the risk of drug-induced thromboembolic events.
Bioactivity Comments
Tegoprubart binds to human CD40LG with an EC50 of 100 ng/ml [1].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
CD40 ligand Hs Antibody Binding - - - 1
⤷ [1]