lunsekimig

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Ligands
lunsekimig

GtoPdb Ligand ID: 14473

Synonyms: F027400161 [2] | SAR-443765 | SAR443765

Compound class: Antibody

Comment: Lunsekimig (SAR443765) is a single chain nanobody that is constructed of five linked antibody (V_HH) domains that simultaneously bind the inflammatory targets thymic stromal lymphopoietin (TSLP) and IL-13, and human serum albumin (ALB). The peptide sequence provided in the INN record matches SEQ ID No 1 in patent US11208476 [2], which equates to clone F027400161 therein.

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
A nanobody designed to simultaneously block TSLP- and IL-13-driven chronic inflammation. Inhibits IL-13-induced eotaxin-3 release and SEAP secretion in vitro [2].

Immunopharmacology Comments

A nanobody designed to simultaneously block TSLP- and IL-13-driven chronic inflammation. Inhibits IL-13-induced eotaxin-3 release and SEAP secretion in vitro [2].