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lunsekimig   Click here for help

GtoPdb Ligand ID: 14473

Synonyms: F027400161 [2] | SAR-443765 | SAR443765
Immunopharmacology Ligand
Compound class: Antibody
Comment: Lunsekimig (SAR443765) is a single chain nanobody that is constructed of five linked antibody (VHH) domains that simultaneously bind the inflammatory targets thymic stromal lymphopoietin (TSLP) and IL-13, and human serum albumin (ALB). The peptide sequence provided in the INN record matches SEQ ID No 1 in patent US11208476 [2], which equates to clone F027400161 therein.
Bioactivity Comments
Neutralises human and monkey TSLP and IL-13 activities [2]. Binds human and monkey serum albumin with nanomolar affinities.
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
thymic stromal lymphopoietin Hs Antibody Binding ~11.8 pKd - 2
⤷ pKd ~11.8 (Kd ~1.7x10-12 M) [2]
IL-13 Hs Antibody Binding ~11.3 pKd - 2
⤷ pKd ~11.3 (Kd ~5.1x10-12 M) [2]