duvakitug

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Ligands
duvakitug

GtoPdb Ligand ID: 14420

Synonyms: TEV-48574 | TEV48574

Compound class: Antibody

Comment: Duvakitug (TEV-48574) is a fully human IgG1λ monoclonal antibody that targets TL1A (TNFSF15) [6]. TL1A signalling through its receptor, death receptor 3 (DR3) modulates inflammatory responses and is implicated in profibrotic pathways [1,3-4]. Based on amino acid sequence matches to the heavy and light chain variable regions of duvakitug we suspect this is antibody clone 320-587 in patent US10138296B2 [5].

Immunopharmacology Comments
TL1A modulates immune pathways that are involved with inflammatory bowel disease and intestinal fibrosis. First-in-human data show that treatment with a anti-TL1A antibody PF-06480605 (to block TL1A/death receptor 3 (DR3) signalling) reduces expression of genes associated with extracellular matrix remodeling and fibrosis [2,6].

Immunopharmacology Comments

TL1A modulates immune pathways that are involved with inflammatory bowel disease and intestinal fibrosis. First-in-human data show that treatment with a anti-TL1A antibody PF-06480605 (to block TL1A/death receptor 3 (DR3) signalling) reduces expression of genes associated with extracellular matrix remodeling and fibrosis [2,6].