GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

duvakitug   Click here for help

GtoPdb Ligand ID: 14420

Synonyms: TEV-48574 | TEV48574
Immunopharmacology Ligand
Compound class: Antibody
Comment: Duvakitug (TEV-48574) is a fully human IgG1λ monoclonal antibody that targets TL1A (TNFSF15) [6]. TL1A signalling through its receptor, death receptor 3 (DR3) modulates inflammatory responses and is implicated in profibrotic pathways [1,3-4]. Based on amino acid sequence matches to the heavy and light chain variable regions of duvakitug we suspect this is antibody clone 320-587 in patent US10138296B2 [5].
No information available.
Summary of Clinical Use Click here for help
Duvakitug (TEV-48574) was progressed as a clinical candidate for inflammatory bowel conditions.
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT05499130 A Study to Test the Effect of TEV-48574 in Moderate to Severe Ulcerative Colitis or Crohn's Disease Phase 2 Interventional Teva Branded Pharmaceutical Products R&D, Inc.
NCT07184996 An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Ulcerative Colitis Phase 3 Interventional Sanofi
NCT07184931 An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease Phase 3 Interventional Sanofi