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LittleLEN 
GtoPdb Ligand ID: 14333
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Synonyms: L-LEN | Little-LEN
Compound class:
Endogenous peptide in human, mouse or rat
Comment: LittleLEN is a C-terminally truncated version of BigLEN, and a naturally-occuring fragment of the endogenous peptide ProSAAS. It has been identified (in mice) as a neuropeptide that selectively binds Gpr50 and activates intracellular Gi signaling [1]. This is the first report of a potential endogenous ligand for GPR50.
Species: Mouse
Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
Peptide Sequence  |
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| LENSSPQAPA | |
| Leu-Glu-Asn-Ser-Ser-Pro-Gln-Ala-Pro-Ala | |
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