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getagozumab   Click here for help

GtoPdb Ligand ID: 14322

Synonyms: GMA-301 | GMA301
Compound class: Antibody
Comment: Getagozumab (GMA301; Gmax Biopharm) is a humanized IgG4 anti-endothelin receptor A (ETA) monoclonal antibody. It acts as an antagonist of receptor function [1].
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Selectivity at GPCRs
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Target Sp. Type Action Value Parameter Concentration range (M) Reference
ETA receptor Hs Antibody Antagonist 8.1 pKd - 1
pKd 8.1 (Kd 8.7x10-9 M) [1]
ETA receptor Hs Antibody Antagonist 7.4 pIC50 - 1
pIC50 7.4 (IC50 3.79x10-8 M) [1]