GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

depemokimab   Click here for help

GtoPdb Ligand ID: 14305

Synonyms: depemokimab-ulaa | Exdensur® | GSK-3511294 | GSK3511294
Approved drug Immunopharmacology Ligand
depemokimab is an approved drug
Compound class: Antibody
Comment: Depemokimab (GSK-3511294) is a humanized IgG1κ monoclonal; antibody that targets interleukin 5 (IL-5). It binds to the same epitope as, but with higher affinity mepolizumab [4].
Bioactivity Comments
Affinity for hIL-5 is ~30-fold more potent compared to the affinity of mepolizumab [4].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-5 Primary target of this compound Hs Antibody Binding - - - 4
⤷ [4]