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delpacibart   Click here for help

GtoPdb Ligand ID: 14255

Compound class: Antibody
Comment: Delpacibart is an anti-TFRC (transferrin receptor) monoclonal antibody. It is being used to deliver conjugated antisense oligonucleotides (ASOs) to target tissues as treatment options for muscular dystrophies [1]. Antibody peptide sequence analysis reveals matches to claims in patent US10913800B2 [2]. Data provided in the patent show that the antibody binds to human and monkey TFRC but does not bind to transferrin receptor 2 (TFR2).
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
References
1. Avidity Biosciences. 
Pipeline Overview.
Accessed on 28/10/2025. Modified on 28/10/2025. aviditybiosciences.com, https://www.aviditybiosciences.com/pipeline/pipeline-overview
2. Darimont BD, Doppalapudi VR, Johna R. (2021)
Anti-transferrin receptor antibodies and uses thereof.
Patent number: US10913800B2. Assignee: Avidity Biosciences Inc. Priority date: 09/06/2020. Publication date: 09/02/2021.