etigilimab

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etigilimab

GtoPdb Ligand ID: 13984

Synonyms: OMP-313M32

Compound class: Antibody

Comment: Etigilimab (OMP-313M32) is an anti-TIGIT monoclonal antibody [1]. Blocking the TIGIT/PVR interaction is proposed to promote anti-tumour immunity. This mechanism is proposed to be used in conjunction with anti-PD/1/PD-L1 immuno-oncology therapeutics, to further enhance the anti-tumour immune response.

Summary
Biological activity
Clinical data
References
Immunopharmacology

Immunopharmacology Comments
Blocks TIGIT/PVR-mediated immune suppression, and has potential to leave PVR available to interact with the costimulatory DNAM-1 (CD226) molecule. This promotes robust anti-tumour immune response by NK and T cells.

Immunopharmacology Comments

Blocks TIGIT/PVR-mediated immune suppression, and has potential to leave PVR available to interact with the costimulatory DNAM-1 (CD226) molecule. This promotes robust anti-tumour immune response by NK and T cells.