GtoPdb is requesting financial support from commercial users. Please see our sustainability page for more information.

compound 669 [WO2021055376A1]   Click here for help

GtoPdb Ligand ID: 13911

Immunopharmacology Ligand
Compound class: Synthetic organic
Comment: This is an orally bioactive small molecule inhibitor of IL-17A interaction with its receptor and IL-17-mediated inflammation [1]. It is one of the compounds that are claimed in Dice Therapeutics' development pipeline. There are two named leads in their pipeline (DC-806 and DC-853 [2]) and a third unnamed lead, but as of May 2025 no name to structure(s) have been formally disclosed for these. DC-806 and DC-853 are both in phase 2 studies for plaque psoriasis.
2D Structure
Click here for help

2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

✖
Click here for structure editor
Physico-chemical Properties
Click here for help

Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/). All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

✖
Hydrogen bond acceptors 10
Hydrogen bond donors 3
Rotatable bonds 15
Topological polar surface area 120.08
Molecular weight 665.79
XLogP 2.56
No. Lipinski's rules broken 2

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
SMILES / InChI / InChIKey
Click here for help

SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

✖
Canonical SMILES CCC(=O)N[C@H]([C@@H](C)C1=CC=C(C(=C1)F)NC(=O)[C@H]([C@H]2CC[C@H](C)CC2)NC(=O)C(C3CCOCC3)(F)F)C(=O)N4CCN(C)CC4
Isomeric SMILES CCC(=O)N[C@H]([C@@H](C)C1=CC(F)=C(NC(=O)[C@@H](NC(=O)C(F)(F)C2CCOCC2)[C@H]3CC[C@H](C)CC3)C=C1)C(=O)N4CCN(C)CC4
InChI InChI=1S/C34H50F3N5O5/c1-5-28(43)39-29(32(45)42-16-14-41(4)15-17-42)22(3)24-10-11-27(26(35)20-24)38-31(44)30(23-8-6-21(2)7-9-23)40-33(46)34(36,37)25-12-18-47-19-13-25/h10-11,20-23,25,29-30H,5-9,12-19H2,1-4H3,(H,38,44)(H,39,43)(H,40,46)/t21-,22-,23-,29+,30-/m0/s1
InChI Key JQJIKYJEWUSKJS-GVIAMBBFSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)
Immunopharmacology Comments
Inhibition of IL-17A signalling is a mechanism that is proposed for the treatment of IL-17-mediated chronic immunology indications. This small molecule binds the cytokine and prevents its interaction with the IL-17 receptor.