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gumokimab   Click here for help

GtoPdb Ligand ID: 13889

Synonyms: AK-111 | AK111
Immunopharmacology Ligand
Compound class: Antibody
Comment: Gumokimab (AK111) is a humanized IgG1 anti-IL-17A monoclonal antibody [2]. It blocks pro-inflammatory cytokine secretion mediated by the IL-17/IL-17 receptor signaling pathway. Based on heavy and light chain CDR sequence matches gumokimab is likely claimed in Akeso's patent EP3805264A1, and is most probably antibody13E9 H3L2 therein [3].
Selectivity at ligand targets
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
IL-17A Hs Antibody Binding 9.3 pKd - 3
⤷ pKd 9.3 (Kd 5.1x10-10 M) [3]
Description: Binding affinity (of mAb 13E9 H3L2) to IL-17A (24-155) determined by biolayer interferometry (BLI)