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manfidokimab   Click here for help

GtoPdb Ligand ID: 13888

Synonyms: AK-120 | AK120
Compound class: Antibody
Comment: Manfidokimab (AK120) is a humanized IgG4 monoclonal antibody that targets the IL-4 receptor alpha (IL-4Rα) subunit that is a component of the IL-4 and IL-13 receptor complexes. It was designed to disrupt signaling mediated by IL-4 and IL-13, in particular to block the pathological T helper 2 (Th2)-mediated inflammatory responses initiated by these cytokines. Peptide sequences for the heavy and light chain domains of manfidokimab match those that form humanized antibody 13E5 H2L2 as claimed in Akeso Pharmaceuticals' patent US20230295312A1 [1].
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
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Summary of Clinical Use Click here for help
Manfidokimab (AK120) is a clinical candidate for the treatment of atopic dermatitis. Clinical development for asthma was terminated (for stragtegic/business reasons).
Clinical Trials
Clinical Trial ID Title Type Source Comment References
NCT04256174 A Study of AK120 (IL-4Rα) in Healthy Subjects and Subjects With Moderate- to- Severe Atopic Dermatitis Phase 1 Interventional Akeso 2
NCT06092762 A Study to Evaluate the Safety and Efficacy of AK120 in Subjects With Moderate to Severe Atopic Dermatitis Phase 2 Interventional Akeso
NCT06383468 A Phase III Study to Evaluate the Efficacy and Safety of AK120 in Patients With Moderate to Severe Atopic Dermatitis Phase 3 Interventional Akeso
NCT06700499 A Study to Evaluate the Efficacy and Safety of AK120 in Subjects With Moderate to Severe Atopic Dermatitis Phase 2 Interventional Akeso